IHC staining revealed significantly increased PD-L1 expression levels in wild-type pancreatic cancer cells in the hyperglycemia group compared to those in the euglycemia group (Fig. 6E), whereas PTRH1 overexpression significantly decreased PD-L1 signal intensity in pancreatic cancer cells in hyperglycemic mice. The gene discussed is CD274; the disease is familial pancreatic carcinoma.