CD274 and neoplasm: It is reported that CA-MSCs of an immune 'hot' mouse OC drived CD8 + T cell tumor immune evasion of CD8 + T cells from tumors and these mouse exhibited a poor response to anti-programmed death ligand 1 (PD-L1) immune checkpoint blockade therapy (ICB) through the secretion of multiple chemokines, such as CCL2, CX3CL1, and TGF-β1 [13].