KEGG pathway analysis demonstrated enriched pathways of Longevity regulating pathway, Longevity regulating pathway-multiple species, Acute myeloid leukemia, Neurotrophin signaling pathway, Non-small cell lung cancer Cellular senescence, Regulation of lipolysis in adipocytes, Endometrial cancer, AMPK signaling pathway and Transcriptional misregulation in cancer (Fig. 5b and Supplementary Table S2). The gene discussed is BDNF; the disease is cancer.