HIF1A and Sepsis: Studies have also demonstrated that IFNγ modulates DC metabolism by converting oxidative phosphorylation to glycolysis through the mTOR/HIF-1α pathway (increasing glycolysis in the cytosol for lactic acid fermentation, not in the mitochondria, through low-rate glycolysis), and restore glycolysis in sepsis-tolerant leucocytes (Cheng et al. 2016; Pantel et al. 2014).