Current immunostimulant drugs include, granulocyte–macrophage colony-stimulating factor (GM-CSF), IFNγ, interleukin 7 (IL-7) and interleukin 15 (IL-15), etc. GM-CSF can significantly improve infection clearance, but the expansion of pathologically activated MDSCs stimulated by GM-CSF cannot be solved, and IL-7 and IL-15 are designed to directly affect the T cell immunity of patients with sepsis.Our previous experiments found that interferon-gamma (IFNγ)-targeted immune enhancement can treat sepsis (Darden et al. 2021). Here, CSF2 is linked to Sepsis.