IFNG and Sepsis: Interestingly, IFNg treats sepsis via the P pathway, and 2-DG inhibits the therapeutic effect of IFNg, but 2-DG has no significant inhibitory effect on PI3K passage, which could potentially imply the existence of other important pathways for IFNg to promote the Warburg effect,a possible speculation is that the RAS/RAF/MEK/ERK/cMyc pathway(Sun et al. 2016; Vaupel and Multhoff 2021).