The epidermal growth factor receptor inhibitor erlotinib also effectively attenuates CD4+ T lymphocyte depletion by downregulating the Warburg effect during sepsis, which promotes mitochondrial damage induced by uncoupling protein 2 in septic acute kidney injury (Yang et al. 2014; Luo et al. 2022; Zhang, et al. 2022; Ji et al. 2021; Huang 2022). The gene discussed is CD4; the disease is acute kidney injury.