Another study also in HIV patients concluded that mutations in the progesterone receptor may reduce the symptoms of acute hepatitis E and protect against infection having found the presence of HEV RNA and/or IgM in 66.7% (26/39) of homozygous wild type patients, 20.5% (8/39) in heterozygous and 12.8% (5/39) in homozygous (López-López et al., 2019). The gene discussed is PGR; the disease is infection.