TGFB1 and neoplasm: Since the MC38 TME immune suppression counteracted the long‐lasting effector function of immune cells induced by POx‐Man nanovaccine (Figure 2), and considering solid tumors biology, we hypothesized that the downregulation of TGF‐β1 secretion and TAM modulation within tumor niche would synergize with the nanovaccine, leading to an extensive activation and expansion of effector immune cells that would ultimately lead to the induction of memory lymphocytes.[6, 7, 20]