CD8A and neoplasm: However, an increased level of tumor‐infiltrating CD8+ T cells expressing PD‐1 was also observed (Figure 4D and Figure S10, Supporting Information) in the tumors of these animals, when compared to PBS‐, Nanovaccine‐, Nanovaccine_siTGF‐β1‐, TIME‐targeted NP‐, and all other divalent combination‐treated groups (p < 0.0001).