CD8A and colorectal carcinoma: High levels of T memory cells have been correlated with a successful relief of disease progression and improved overall and disease‐free survival in CRC patients.[24] In this intervention therapeutic study, the highest systemic levels of CD8+ T effector memory cells (Figure S11A,D, Supporting Information), which can recirculate through non‐lymphoid tissues and the blood, were obtained for the divalent therapy Nanovaccine_siTGF‐β1 + Pexidartinib (p < 0.0001).