The p22phox and gp91phox deficient patients had the highest percent of gastrointestinal tract (GIT) symptoms (perianal abscess, organomegaly, diarrhea, IBD), and regional BCG-itis with a significant statistical difference, while mycobacterial infections were highest among P47phox deficient followed by P22phox deficient patients (59% and 33.3%, respectively). This evidence concerns the gene CYBA and inflammatory bowel disease.