The TYR subgroup is characterised by overexpression of melanosomal genes and tumours predominantly occur in the infratentorial region, the SHH group has overexpression of the Sonic Hedgehog pathway and occur equally in infra- and supratentorial locations, and the MYC group overexpresses genes in the MYC and HOX cluster and are most commonly supratentorial tumours [33]. This evidence concerns the gene TYR and neoplasm.