APOE and Alzheimer disease: This IV:4 patient has an APOE ε4ε4 genotype, a positive family history and early onset age and scored in the high-risk category g5 (ALL_WA model wGRS = 4.96) [45], where a great amount of discriminative ability of the GRS was attributable to the APOE genotype, positive family history of AD and early onset age.