FLT4 and metastatic malignant neoplasm in the lymph nodes: The results showed that increased number of D2-40+FGFR1+, D2-40+VEGFR3+ and D2-40+HK2+ cells are associated with increased lymph node metastasis in iCCA (Fig. 5K, L, M, Sup Table S2, S3 S4), which hinted that lymphangiogenesis may correlated with lymph node metastasis in iCCA.