The results showed that increased number of D2-40+FGFR1+, D2-40+VEGFR3+ and D2-40+HK2+ cells are associated with increased lymph node metastasis in iCCA (Fig. 5K, L, M, Sup Table S2, S3 S4), which hinted that lymphangiogenesis may correlated with lymph node metastasis in iCCA. The gene discussed is PRRT2; the disease is infantile convulsions and choreoathetosis.