We identified both known gene expression markers for GBM prognosis, such as PTPRZ145 and EGFR46, as well as markers that were previously uninvestigated, such as SNRPD3, TPST1 and GUCD1. Overall, genes upregulated in high-aggressive regions were related to glycoprotein metabolism, antigen processing and response to axon injury. This evidence concerns the gene GUCD1 and glioblastoma.