Likewise, other vascular beds, e.g., aorta derived from diabetic GK rats and isolated vessels from T2D humans, exhibited a preserved and enhanced relaxation response to sGC activators (i.e., heme-independent activator protoporphyrin-IX and BAY 58–2667, respectively) [167, 177]. The gene discussed is SGCB; the disease is type 2 diabetes mellitus.