TP53 and head and neck squamous cell carcinoma: The findings of this study indicate that the typical features of SNAFs are as follows: (1) they are grossly exophytic with highly inflamed stroma, (2) they are difficult to diagnose and require repeated biopsies, (3) they tend to show a relatively slow-growing feature, and (4) when compared with ordinary HNSCC, SNAFs exhibit a lower incidence of altered p53 type/TP53 mutation and a relatively high p16 positivity rate22.