PDX1 and familial pancreatic carcinoma: Then, we established an immunocompetent orthotopic pancreatic cancer mouse model, and confirmed that the orthotopic pancreatic tumour had highly consistent pathological and immune features with the pancreatic tumours derived from KrasLSL-G12D; Tp53fl/-; Pdx1-Cre mice (Supplementary Fig. 5a, b).