MAPT and Alzheimer disease: NFTs have also been found to be spatially correlated with neuroinflammation in clinical samples from AD patients.45 Meng et al. further demonstrated that the hyperphosphorylated tau can disrupt membrane bilayers and activate human macrophages through TLR4.46 Recently, Welikovitch et al. found that soluble and oligomeric amyloid protein-burdened neurons exhibited a unique inflammatory profile.