TREM2 and Cognitive impairment: In contrast, STING stimulator, cGAMP, was found to induce triggering receptor expressed on myeloid cells 2 (TREM2) expression, which has been suggested to decrease Aβ deposition and improve cognitive impairment in AD.407 So the exact function of cGAS-STING signaling in AD is still far from understanding, studies in the future need to clarify the role of different face of cGAS-STING in affecting the development of AD.