Single-nucleus RNA sequencing (snRNA-seq) data on postmortem samples from AD patients and on samples from AD mice model also revealed that the expression of TREM2 was increased in AD pathology.164,213,214 Further studies suggested that TREM2 was prominently upregulated in microglia around the lesion regions in a disease progression-related manner,215–217 although the other studies revealed that TREM2 positive cells were recruited monocytes rather than microglia.218,219 Expression of TREM2 can be induced by several ways. The gene discussed is TREM2; the disease is Alzheimer disease.