Of note, sVCAM1 levels correlated significantly with disease severity.491 In in vitro study, Aβ/RAGE interaction also induced the expression of CCR5 receptor, which was suggested responsible for the migration of MIP-1α (a CCR5 ligand)-expressing T cells (isolated from AD patient) through in vitro BBB model,492 and the expression of cationic antibacterial proteins, which enhanced the adhesion of monocytes to endothelial cells and exacerbated inflammatory reaction in endothelial cells.493. The gene discussed is AGER; the disease is Alzheimer disease.