TARDBP and amyotrophic lateral sclerosis: The proper expression of IL-6 by pericytes was suggested to be important for the integrity of BBB.507,508 In an in vitro experiment, Scotter et al. found that dysfunction of TDP-43 in pericytes suppressed the expression of IL-6 by pericytes,509 indicating that TDP-43 loss-of-function may contribute to the pathology of ALS by disrupting the function of pericytes.