NOS2 and Parkinson disease: Analysis of post-mortem human brain samples revealed increased levels of iNOS PD.460 In addition, iNOS expression was also found to be enhanced in multiple PD animal models induced by 6-OHDA,461 MPTP,462 and aSyn oligomers.463 NOS inhibition protected neuron from death in PD mouse models.464–467 These findings indicate that NO signaling is enhanced in PD and intervention of NO signaling may have potential for the treatment of PD.