UBE2E3 and Parkinson disease: Multiple common genetic variants between PD patients and other inflammatory diseases have been identified.249,250 In addition, GWAS have identified several immune-related gene variants in PD,251 including leucine rich repeat kinase 2 (LRRK2), glucosylceramidase (GBA), parkin RBR E3 ubiquitin protein ligase (PRKN) and PTEN Induced Kinase 1 (PINK1).