NFKB1 and Alzheimer disease: As we discussed above, many receptors (i.e., TLR, P2Y6, CSF-1R), signal transducers (i.e., JAK, p38 MAPK, ERK), activators of transcription (i.e., STAT, NF-κB) and inflammatory mediators (i.e., GM-CSF, TNF-α, NO) are involved in neuroinflammation and AD development.