PRKN and Parkinson disease: Knockout of STING reverses motor deficit and neuron loss in aged PRKN knockout PD mouse model.268 In addition, an important study published recently found that mice carrying STING N153S, a constitutively active STING, was sufficient to induce α-synuclein aggregation and degeneration of dopaminergic neurons.410 This study shows up the crucial role of cGAS-STING pathway in the development of PD.