The pathology of AD is characterized by extracellular amyloid plaques and intracellular NFTs, which are surrounded by immune cells, especially microglia; the clinical manifestation of AD is characterized by progressive cognitive impairment.14 The main component of the amyloid plaques is amyloid beta (Aβ), which is generated by improper cleavage of the amyloid precursor protein (APP), and the NFTs are composed of hyperphosphorylated microtubule-binding protein tau. The gene discussed is APP; the disease is Alzheimer disease.