Study using APOE4 target replacement mice revealed that APOE4 can increase the expression of miRNA146a,178 which was found to be highly expressed in AD, reducing the expression of its target protein complement factor H, an important repressor of the inflammatory response of the brain.179 Using astrocyte differentiated from human induced pluripotent stem cells, Arnaud et al. found that APOE4 decreased the expression of Transgelin 3 in astrocytes, ultimately led to the activation of astrocytes through NF-kB pathway.180 But there are also some conflicting results. The gene discussed is APOE; the disease is Alzheimer disease.