Inhibiting the expression of NLRP3 by microRNA can ameliorate α-synuclein aggregation and protect dopaminergic neurons against degeneration in a mouse model of PD.360 MCC950, a specific NLRP3 inhibitor, exerted neuroprotective effects and improved behavioral dysfunctions in an MPTP-induced PD mouse model.563 These exciting results in animals led them to seek a clinical trial. Here, NLRP3 is linked to Parkinson disease.