Recently, higher level of pro-inflammatory eicosanoid lipidome was found in APOE4 carrying older persons with AD compared with non-carriers, indicating that APOE4 may affect the molecules involved in eicosanoid metabolism.175 In addition, APOE4 was found to reduce the phagocytosis ability of glial cells, enhance microglia proinflammatory activation by Aβ plaques or tau aggregates and promote neurodegeneration in the mouse models.176,177 Although the underlying molecular mechanism is still far from clear, some clues have been found. This evidence concerns the gene MAPT and Alzheimer disease.