Nicotinamide riboside (NR), a NAD+ precursor, has been suggested to decrease the activation of glial cells partly through regulating the cGAS-STING signaling.403,404 Jin et al. reported an interesting finding that AD pathogenic protein tau can bind to polyglutamine binding protein 1 (PQBP1) and trigger inflammation in the CNS by activating cGAS-STING pathway.405 Recently, Xie et al. found that cGAS-STING pathway microglia was activated in aged mice and human AD. The gene discussed is CGAS; the disease is Alzheimer disease.