TARDBP and amyotrophic lateral sclerosis: Additionally, in SH-SY5Y cells homozygously expressing the ALS-related N352S variant of TDP-43 and displaying the described defects of STMN2 pre-mRNA processing, the authors show that not only MCP, but also the nuclease-dead CRISPR effector RfxCas13d (dCasRx) can compensate for the steric block function of TDP-43 when guided to the right position in exon 2a.