At age 10, he was hospitalized for a ruptured ascending aortic aneurysm, and genetic testing identified a pathogenic variant in both TGFBR2 and COL2A1. These findings resulted in a dual diagnosis of Loeys–Dietz syndrome Type 2 and Stickler syndrome. This evidence concerns the gene COL2A1 and Ascending tubular aorta aneurysm.