Four high-confidence effector genes reside in the two genomic regions that do not show any evidence of colocalization or association with the analyzed measures of adiposity: TMEM176A, RARRES2, SMARCD3, and GLIS3. These may point to alternative biological mechanisms other than adiposity in the comorbidity between type 2 diabetes and osteoarthritis for these colocalizing signals. The gene discussed is TMEM176A; the disease is osteoarthritis.