TCF7L2 and type 2 diabetes mellitus: Additionally, we found evidence that an increase in TCF7L2 expression in pancreatic islets causes an increase in type 2 diabetes risk (OR = 5.1, 95% CI = [4.7, 5.4], p value < 1 × 10−300, F stat = 2,018) and a decrease in knee osteoarthritis risk (OR = 0.83, 95% CI = [0.77, 0.91], p value = 1.77 × 10−5, F stat = 18.4).