Higher ICI-4W expression of extracellular matrix (ECM) genes, including trypsinogens (PRSS1 and PRSS2) and matrix metalloproteases, and genes encoding cancer antigens (CTAG2, SAGE1, MAGEA1/A4/A10, POTEE, and PRAME) was significantly associated with ICI resistance and tumor growth during ICI-4W (Figures 2F and S3D–S3F, and Table S3). This evidence concerns the gene PRSS2 and cancer.