Conversely, upregulation of E2F targets (e.g., PRDX4, MCM2; FDR = 2.6e-24) and extracellular matrix genes (e.g., COCH, MATN3; FDR = 8.0e-18) were strongly associated with tumor growth and resistance to ICI-4W (Figures 2D, S2E, and S2F). The gene discussed is COCH; the disease is neoplasm.