Our aim was to investigate the presence of the SapS gene in 12 strains of S. aureus isolated from infected bone samples of patients treated for chronic osteomyelitis and in 49 S. aureus strains from a database containing in silico complete bacterial genomes, determine SapS presence and activity in partially purified protein extracts from supernatants of the clinical strains culture media, and compare them with those previously described .8 Here, SKAP2 is linked to osteomyelitis.