Similarly, in TCGA database bladder cancer samples, CCN1 (p=7.9e-07), MYC (p=0.0043), POU5F1 (p=0.021), and TGFB1I1 (p=6.0e-05) had significant differences in bladder cancer high-grade and low-grade samples, in addition to IRF5 (p=0.2) (Figure 3B). The gene discussed is IRF5; the disease is urinary bladder cancer.