To screen for the best senescence-related prognostic genes for bladder cancer, we included these five genes with clinicopathological parameters (age, sex, TNM stage, and grade) in univariate and multifactorial Cox regression models, and the results of multifactorial Cox regression analysis indicated that among these five genes, IRF5 and MYC could be used as prognostic biomarkers in bladder cancer (Figure 3C, 3D). Here, IRF5 is linked to urinary bladder cancer.