The coexistence of type 2 diabetes mellitus (T2DM) and hypertension (HT) also increased the mortality and severity of COVID-19 infection by altering the balance between the ACE1/Ang2 and ACE2 systems and the interaction of SARS-CoV-2 with the host [19–21]. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.