In the present study, the function of DMKN, as well as its relationship with malignancy in melanoma cancer was examined by analyzing the mRNA and protein expression of DMKN-α, DMKN-β, and DMKN-β/γ in the aggressive amelanotic human melanoma cell line (C8161), uveal melanoma cell line (MUM-2B), and two other advanced melanoma cell lines (SK-MEL-28 and A375) (Fig 1A and 1B). Here, DMKN is linked to melanoma.