PYCR1 and allergic asthma: In addition, we found that a reduction in endogenous or exogenous proline may attenuate inflammation and remodeling in asthma, demonstrating that Pycr1 deficiency or starvation of proline could prevent airway remodeling in HDM-induced allergic asthma, warranting further investigation of proline and PYCR1 as therapeutic targets for asthma.