AKT1 and allergic asthma: PYCR1, which is upregulated in human asthmatic epithelial cells and HDM-induced murine allergic asthma models, prompts the synthesis of proline, which is critical for airway inflammation, hyperresponsiveness, and remodeling by modulating mitochondrial damage and metabolic reprogramming in airway epithelial cells, along with the activation of downstream pro-remodeling AKT/mTORC1 and WNT3a/β-catenin signaling.