ADRB2 and asthma: It is important to note that, despite the more profound bronchoprotective effect against ovalbumin-induced constriction, there was still an appreciable bronchoprotective effect of Cmpd-6 against methacholine-induced airway constriction — particularly in human lung slices — suggesting that PAMs of the β2AR will benefit patients with asthma irrespective of the stimulus that causes their airway constriction.