A recent study suggests that the reduction in social anxiety- and despair-like behavior in rats after FTY720 treatment may be attributed to reduced mRNA levels of angiopoietin 1, endothelin 1, plasminogen, transforming growth factor beta 2, and matrix metallopeptidase 2 in the medial prefrontal cortex and, consequently, decreased vascular remodeling after drug treatment [98]. This evidence concerns the gene PLG and Anxiety.