Since obesity is closely related to T2DM, and Alzheimer’s disease (AD) is also recognized as “type III diabetes,” we checked the expression of genes encoding proteins that are involved in amyloid-beta (Aβ) generation (ADAM10, BACE1, PSEN2, and GSK3β) [62]. The gene discussed is BACE1; the disease is obesity due to melanocortin 4 receptor deficiency.