This study has revealed that 6-shogaol suppresses the development of heart failure caused by LVH and LV systolic dysfunction, which are exacerbated by cardiomyocyte hypertrophy and cardiac fibrosis, by inhibiting p300-HAT activity, a downstream signaling pathway that is common to cardiomyocytes and cardiac fibroblasts, in pressure-overload-induced heart failure model mice. This evidence concerns the gene TMPRSS11D and heart failure.