The TAS2R38 receptor is thought to influence thyroid function for the following reasons: (1) PROP is an agonist of TAS2R38 which has been indicated in the treatment of hyperthyroidism by thyroid peroxidase inhibition [24]; (2) It was found that some members of the TAS2R family (TAS2R4, TAS2R10 and TAS2R40) inhibit the TSH-dependent increase in Ca2+ and iodine efflux in thyrocytes [21]; (3) Non-bitter tasters demonstrated higher ingestion of bitter tasting compounds such as vegetables of the Brassica family, which can inhibit thyroid hormonal synthesis [7,25,26]. The gene discussed is TAS2R38; the disease is hyperthyroidism.