IFNG and viral infectious disease: These data are consistent with previous research demonstrating aqueous extracts from the mycelium of TV decrease IFN-γ from unstimulated PBMC cultures in a dose-dependent manner [9], suggesting a reduced Th1 response required for anti-viral immunity, as robust T-helper 1 (Th1) responses to virus infection, consisting of IFN-γ-secreting T cells specific to the virus and cytotoxic T cells, is required for the clearance of infection [24,25].