Interestingly, a study comparing the timing of dietary intervention in a mouse model of maternal obesity found that dietary intervention only 1 week prior to conception did not alleviate the risks associated with maternal obesity for the offspring as they exhibited disrupted insulin sensitivity in hepatocytes, increased hepatic expression of SREBP-1c and hepatic steatosis, like the offspring of mothers with obesity. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.