Specifically, in obesity, dysfunctional adipose tissue predominantly secretes proinflammatory adipokines (e.g., leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)) in detriment of the anti-inflammatory ones (e.g., adiponectin). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.