MMP9 and myeloid sarcoma: Clioquinol (CQ) and ZnT3 gene deletion were shown to significantly suppress EAE (an animal model of MS)-associated clinical features and neuropathological changes, as well as inhibit MMP-9 activation, BBB disruption and immune cell infiltration, implying the involvement of synaptic Zn2+ in myelin damage of spinal cord white matter [227,228].