Based on the KEGG enrichment analysis, 81 signaling pathways (p ≤ 0.05) were obtained, involving the pathway in cancer, HIF-1, PI3K-Akt, Prolactin, Relaxin, and Toll-like receptor signaling pathway, etc. Subsequently, the top 25 pathways were visualized and analyzed with advanced bubble plots (Figure 3d). This evidence concerns the gene HIF1A and cancer.