HMOX1 and breast carcinoma: Luteolin was found to suppress the expression of key transcription factors associated with stemness, as well as the expression of ABCG2, aldehyde dehydrogenase 1, CD44, Cripto-1, heme oxygenase 1, and Nrf2, all of which play crucial roles in sustaining the cancer stem-cell phenotype of breast cancer [126].