Although FO did not increase the percentage of brain DHA in APOE4, a 17.1% (p < 0.05) and 20.0% (p < 0.001) higher DHA level in the PC fraction of the HF FO and HF FO + FLAV groups, and a 14.5% (p < 0.05) higher DHA level in the PE fraction of the HF FO + FLAV group was evident in these animals relative to the HF controls. Here, APOE is linked to hydrops fetalis.