Since the loss of genome integrity through the failure of mechanisms to silence transposable elements may contribute to ageing-related cognitive decline [114], it is possible that the upregulation of KCNQ1OT1 may retard cellular ageing and hence protect the neuronal networks underpinning the enhanced cognitive repertoire of Aged enriched WT mice. This evidence concerns the gene KCNQ1OT1 and Mental deterioration.