Statin use was significantly associated with lower global cognitive performance (β = −.403 [−0.531, −0.276], p = <.0001) after adjustments for assessment center, age, sex, education, APOE4 status, TDI, ethnicity, alcohol use, smoking, BMI, physical activity, history of diabetes, stroke, hypertension, CHD, and considering interactions between statin and sex, ethnicity, diabetes, hypertension, or CHD (Supplementary Table 2). The gene discussed is APOE; the disease is Hypertension.