A hallmark of cancer is the great versatility of metabolic enzymes in cancer cells during tumor progression and evolution, which is reflected by the ability of cancer cells to exert canonical and noncanonical functions.[19] In this study, we observed that high expression of ALDOA correlates with a poor prognosis in patients with HCC and is functionally critical for liver cancer malignancy. Here, ALDOA is linked to hepatocellular carcinoma.