Further analyses of ALDOA mRNA levels in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus  databases demonstrated that increased expression of ALDOA is often observed in HCC patients (Figure 1d,e; Figure S1b, Supporting Information) and high expression of ALDOA is associated with poor survival and pathological characteristics, including TNM stage and tumor size (Figure 1f,g; Figure S1c,d, Supporting Information). This evidence concerns the gene ALDOA and neoplasm.