MBP and multiple sclerosis: In the blood serum of patients with multiple sclerosis, immunoglobulins (Ig) hydrolyzing myelin basic protein (MBP) (IgG (Polosukhina et al., 2004; Parshukova et al., 2020b; Parshukova et al., 2019), IgA and IgM  (Polosukhina et al., 2005)), as well as IgGs with catalytic activity to histones (Baranova et al., 2019) and to oligodendrocyte progenitor cell surface proteins of oligodendrocyte precursors (Niehaus et al., 2000) have been reported.