The guidance cue Netrin-1 participates in the developmental organization of neural networks by either attracting or repelling extending axons and dendrites and is highly expressed in terminal fields of mesocorticolimbic DA neurons including the PFC.50 Responses to Netrin-1 can be modulated by regulating the availability of DCC (deleted in colorectal cancer) and UNC5 (uncoordinated) receptors. This evidence concerns the gene NTN1 and colorectal cancer.