Studies have demonstrated that strains such as L. plantarum CRL1506, MPL16 and LRCC5310 are able to regulate the Toll-like receptor 3 (TLR3)-mediated immune response in the intestinal mucosa and to increase the production of interferon (IFN)-γ and IFN-β as well as antiviral factors increasing the protection against viral infections [4,5,6,7]. This evidence concerns the gene TLR3 and viral infectious disease.