In addition, after acrolein treatment, the nigra-striatal pathway and the primary DA synthesis pathway were activated and maladjusted, respectively, which could change the TH phosphorylation site in the whole brain [70] and decrease the activity of complex I (the main component of the electron transport chain) in the substantia nigra and frontal cortex of PD patients [57]. This evidence concerns the gene TH and Parkinson disease.