It has been reported that hyperglycemia, dyslipidemia, inflammation, and insulin resistance in T2DM were ameliorated after the oral administration of Scutellariae Radix and Coptidis Rhizoma, two types of traditional Chinese medicines, via regulating the PI3K/AKT signaling pathway [39], indicating that AKT activation was involved in glycometabolism regulation. This evidence concerns the gene AKT1 and Insulin resistance.