We aimed to adjust for established clinical CVD risk factors such as cholesterol, blood pressure, glycosylated hemoglobin (HbA1c), body mass index (BMI), Visceral Adiposity Index, waist circumference, leptin and C-reactive protein (CRP), in order to evaluate if elevations were beyond the degree of obesity. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.