ARMS2 and age-related macular degeneration: cCSCR, PCV and AMD may share similar genetic and pathophysiologic characteristics, as proven by some studies which have shown that cCSCR is associated with genetic variants in ARMS2 and CFH. There are significant disparities in allele frequencies among the phenotypic subgroups of the tested single nucleotide polymorphisms (SNPs) which are also associated with AMD.