AKT1 and colorectal carcinoma: Intriguingly, at steady state, we observed a tendency that B56γ3 overexpression upregulated AKT phosphorylation, whereas B56γ3 knockdown decreased AKT phosphorylation at Ser473 and Thr308, hallmarks of AKT activation, in CRC cell lines HCT116, SW480, and DLD-1 (Fig. 1 and Supplementary Fig. 1).