SNAI1 and colorectal carcinoma: In addition, when CRC cells were treated with AKT-specific siRNAs to knock down AKT1/2 expression, results showed that reduced expression of AKT1/2 by siRNAs blocked B56γ3-mediated increases in SNAIL levels, cell motility and invasion of HCT116 and SW480 cells (Fig. 5G-J and Supplementary Fig. 8).