As shown in Fig. 4H, tumor cells from the IgG and PD-1 groups were mainly clustered in the invasive and migrative branches (H3F3B+ and FOSB+ tumor cells), while cells from the SMI group were mainly clustered in the CSCs and EMT branches (NEAT1+ and S100A4+ tumor cells). The gene discussed is PDCD1; the disease is neoplasm.