VEGFA and neoplasm: H3F3B+ tumor cells were primarily present in the IgG group (Fig. 4C), in which the vascular endothelial growth factor (VEGF) A-vascular endothelial growth factor receptor (VEGFR) 2 signaling, positive regulation of growth, and receptor tyrosine kinase signaling pathways were enriched (Fig. 4D and Additional file 1: Fig. S10A).