Moreover, we inferred three NK subclusters, particularly, the GZMAhigh NK cells, may receive strong signals from M1-like macrophages (IL1B+ Mø, IL6+ Mø, CCL5+ Mø, and IFITM3+ Mø) as well as S100A4+ and NEAT1+ tumor cells via CXCL10-CXCR3 (Fig. 6H), which is essential for the recruitment of NK cells into the TME [57]. Here, IFITM3 is linked to neoplasm.