As the results showed in the Table 5, with the increase of serum TNF-α, IL-6 and VEGF levels, the risk of death in elderly patients with colon cancer was significantly increased (all OR > 1, P < 0.001), indicating that TNF-α, IL-6 and VEGF were all independent risk factors for death in elderly patients with colon cancer. The gene discussed is TNF; the disease is colonic neoplasm.