Meanwhile, KEGG pathway enrichment analysis revealed that Hepatitis B (hsa05161; P-value = 4.01E-04), Natural killer cell mediated cytotoxicity (hsa004650; P-value = 9.67E-04), T cell receptor signaling pathway (hsa04660; P-value = 0.014464904), TNF signaling pathway (hsa04919; P-value = 0.000616), Apoptosis (hsa04210; P-value = 0.020497316) and B cell receptor signaling pathway (hsa04662; P-value = 0.018129562) were significantly enriched, as shown in Table 2. Here, TNF is linked to hepatitis B virus infection.