In our research, the mRNA expressions of CBX family (especially CBX1, CBX5, and CBX6) in DLBCL were significantly correlated with the infiltration of most immune cells (including B cells, CD8+ T cells, CD4+ T cells, neutrophils, monocytes, macrophages, and Treg cells). This evidence concerns the gene CBX6 and diffuse large B-cell lymphoma.